Androgen Receptor is Responsible for Rat Organic Cation Transporter 2 Gene Regulation but not for rOCT1 and rOCT3

@article{Asaka2006AndrogenRI,
  title={Androgen Receptor is Responsible for Rat Organic Cation Transporter 2 Gene Regulation but not for rOCT1 and rOCT3},
  author={Jun-ichi Asaka and Tomohiro Terada and Masahiro Okuda and Toshiya Katsura and Ken-ichi Inui},
  journal={Pharmaceutical Research},
  year={2006},
  volume={23},
  pages={697-704}
}
Organic cation transporters 1–3 (OCT1–3; Slc22a1–3) mediate the membrane transport of organic cations in the kidney. We previously reported that rat (r)OCT2 expression in the kidney was regulated by testosterone. In this study, we examined the transcriptional mechanisms underlying the testosterone-dependent regulation of rOCT2 expression. Approximately 3000-bp fragments of the rOCT1–3 promoter region were isolated, and promoter activities were measured in the renal epithelial cell line LLC-PK1… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

OCT1, 2, and 3 (SLC22A1Y3)

  • J. W. Jonker, A. H. Schinkel. Pharmacological, physiological functions of the polyspecific organic cation transporters
  • J. Pharmacol. Exp. Ther. 308:2Y9
  • 2004
1 Excerpt

Similar Papers

Loading similar papers…