Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases

  title={Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases},
  author={X. Zhang and C. Morrissey and Shihua Sun and Melanie Ketchandji and P. Nelson and L. True and F. Vakar‐Lopez and R. Vessella and S. Plymate},
  journal={PLoS ONE},
  • X. Zhang, C. Morrissey, +6 authors S. Plymate
  • Published 2011
  • Biology, Medicine
  • PLoS ONE
  • Background Although androgens are depleted in castration resistant prostate cancer (CRPC), metastases still express nuclear androgen receptor (AR) and androgen regulated genes. We recently reported that C-terminal truncated constitutively active AR splice variants contribute to CRPC development. Since specific antibodies detecting all C-terminal truncated AR variants are not available, our aim was to develop an approach to assess the prevalence and function of AR variants in prostate cancer… CONTINUE READING
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