Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases

@inproceedings{Zhang2011AndrogenRV,
  title={Androgen Receptor Variants Occur Frequently in Castration Resistant Prostate Cancer Metastases},
  author={Xiaotun Zhang and Colm Morrissey and Shihua Sun and Melanie Ketchandji and Peter S. Nelson and Lawrence D. True and Funda Vakar-Lopez and Robert L. Vessella and Stephen R. Plymate},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Although androgens are depleted in castration resistant prostate cancer (CRPC), metastases still express nuclear androgen receptor (AR) and androgen regulated genes. We recently reported that C-terminal truncated constitutively active AR splice variants contribute to CRPC development. Since specific antibodies detecting all C-terminal truncated AR variants are not available, our aim was to develop an approach to assess the prevalence and function of AR variants in prostate cancer… CONTINUE READING

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