Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer

@article{Wang2009AndrogenRR,
  title={Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer},
  author={Qianben Wang and Wei Li and Yong Zhang and Xin Yuan and Kexin Xu and Jindan Yu and Zhuotong Chen and Rameen Beroukhim and Hongyun Wang and Mathieu Lupien and Tao Wu and Meredith M. Regan and Clifford A. Meyer and Jason S. Carroll and Arjun K. Manrai and Olli A. J{\"a}nne and Steven P. Balk and Rohit Mehra and Bo Han and Arul M. Chinnaiyan and Mark A. Rubin and Lawrence D. True and Michelangelo Fiorentino and Christopher Fiore and Massimo Loda and Philip W. Kantoff and Xiaole Shirley Liu and Myles Brown},
  journal={Cell},
  year={2009},
  volume={138},
  pages={245-256}
}
The evolution of prostate cancer from an androgen-dependent state to one that is androgen-independent marks its lethal progression. The androgen receptor (AR) is essential in both, though its function in androgen-independent cancers is poorly understood. We have defined the direct AR-dependent target genes in both androgen-dependent and -independent cancer cells by generating AR-dependent gene expression profiles and AR cistromes. In contrast to what is found in androgen-dependent cells, AR… Expand
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