Androgen-Receptor Blockade Does Not Impair Bone Mineral Density in Adolescent Females

@article{Bertelloni1997AndrogenReceptorBD,
  title={Androgen-Receptor Blockade Does Not Impair Bone Mineral Density in Adolescent Females},
  author={Silvano Bertelloni and Giampiero Igli Baroncelli and Mariangela Sorrentino and Sabrina M R J Costa and Roberta Battini and Giuseppe Saggese},
  journal={Calcified Tissue International},
  year={1997},
  volume={61},
  pages={1-5}
}
The effect of peripheral androgen hypersensitivity on bone mineral density (BMD) was investigated in a group of adolescent women with idiopathic hirsutism (n= 17; mean age 17.0 ± 1.7 years). The effect of long-term androgen-receptor blockade with flutamide (500 mg daily in two divided doses for 12 months) on BMD was assessed too. BMD was measured at lumbar spine (L2–L4) by a dual energy X-ray densitometer. Before flutamide treatment, patient BMD (1.14 ± 0.07 g/cm2) was not significantly… CONTINUE READING