Androgen Dependent Tumorigenesis in Rat Thyroid Gland Induced by Diisopropanolnitrosamine (DIPN) Administration


Employing diisopropanolnitrosamine (DIPN)-induced rat thyroid tumors as an experimental model, the possible role of androgen in thyroid carcinogenesis was examined. The rate of tumer induction was higher in male than female rats. In male rats, at 15 to 20 weeks after the final DIPN iajection, the thyroid glands were remarkably enlarged and were being… (More)


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