Androgen Deficiency, Meibomian Gland Dysfunction, and Evaporative Dry Eye

@article{Sullivan2002AndrogenDM,
  title={Androgen Deficiency, Meibomian Gland Dysfunction, and Evaporative Dry Eye},
  author={David A. Sullivan and Benjamin D. Sullivan and James E. Evans and Frank Schirra and Hiroko Yamagami and Meng Liu and Stephen M. Richards and Tomo Suzuki and Debra A. Schaumberg and Rose M. Sullivan and Mohamad R. Dana},
  journal={Annals of the New York Academy of Sciences},
  year={2002},
  volume={966}
}
Abstract: Objective. We have recently discovered that women with primary and secondary Sjögren's syndrome are androgen‐deficient. We hypothesize that this hormone insufficiency contributes to the meibomian gland dysfunction, tear film instability, and evaporative dry eye that are characteristic of this autoimmune disorder. If our hypothesis is correct, we predict: (1) that androgens regulate meibomian gland function, control the quality and/or quantity of lipids produced by this tissue, and… 

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Therapy of dry eye is usually based upon topical administration of tear substitutes; estrogen or androgen-based eye drops represents a promising innovative treatment based upon important scientific rationale.

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...

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