Androgen Ablation Leads to an Upregulation and Intranuclear Accumulation of Deoxyribonuclease I in Rat Prostate Epithelial Cells Paralleling Their Apoptotic Elimination

@article{Rauch1997AndrogenAL,
  title={Androgen Ablation Leads to an Upregulation and Intranuclear Accumulation of Deoxyribonuclease I in Rat Prostate Epithelial Cells Paralleling Their Apoptotic Elimination},
  author={Frank Rauch and Bernhard Polzar and Harald Stephan and Silvia Zanotti and Renate Paddenberg and Hans Georg Mannherz},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={137},
  pages={909 - 923}
}
After androgen ablation by castration, the epithelial cells of the rat ventral prostate are eliminated by apoptosis. The number of cells showing apoptotic chromatin degradation increases with time up to day 3 after castration as verified by in situ end labeling of fragmented DNA. Apoptotic chromatin degradation is catalyzed by a Ca2+, Mg2+-dependent endonuclease. Recently, evidence has been presented that suggests deoxyribonuclease I (DNase I) is identical or very closely related to the… CONTINUE READING
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