Androgen/androgen receptor pathway regulates expression of the genes for cyclooxygenase-2 and amphiregulin in periovulatory granulosa cells

@article{Yazawa2013AndrogenandrogenRP,
  title={Androgen/androgen receptor pathway regulates expression of the genes for cyclooxygenase-2 and amphiregulin in periovulatory granulosa cells},
  author={Takashi Yazawa and Shinya Kawabe and Masafumi Kanno and Tetsuya Mizutani and Kaoru Miyamoto},
  journal={Molecular and Cellular Endocrinology},
  year={2013},
  volume={369},
  pages={42-51}
}
It is well known that the androgen/androgen receptor (AR) pathway is involved in both male and female fertility in mammals. AR knockout female mice are reported to exhibit various abnormalities in follicle development, and a subfertile phenotype. In exogenous gonadotropin-induced superovulation, serum androgen levels were robustly elevated in female mice at the periovulatory stage after human chorionic gonadotropin (hCG) treatment. At this stage, ovarian AR proteins were strongly expressed in… CONTINUE READING
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