The -863 TNF-α Polymorphism and Primary Open Angle Glaucoma in Egyptians
PURPOSE We evaluated the positive rate of the Anderson criteria of suspected early glaucomatous visual field defects (GVFDs). SUBJECTS AND METHODS Ninety-six eyes of 96 patients, who had suspected primary open-angle glaucoma with apparent glaucomatous optic disc changes and who had more than -6.0 dB of mean deviation (MD) with Swedish Interactive Thresholding Algorithm Standard (SITA-S) Central 30-2 program in the Humphrey Field Analyzer, were selected. We applied the Anderson criteria and calculated the positive rates for these criteria and for three elements pattern deviation probability plots (PD plots), glaucoma hemifield test (GHT), pattern standard deviation (PSD). RESULTS The positive rate of the Anderson criteria was 78.1% and the PD plots (77.1%) were significantly higher rate than the GHT (62.5%) or the PSD (63.5%). The positive rate of the Anderson criteria was 100% in the MD of less than -3.0 dB and was 65.6% even in the MD of more than -3 dB (p < 0.0001). On the other hand, 57.9% of the eyes with an MD between -2 dB and -1 dB showed positive in all elements. At more than -1.0 dB of MD, the PD plots (50.0%) were significantly higher than the PSD (18.8%) or the GHT (21.9%) (PSD: p = 0.0085, GHT : p = 0.0190). CONCLUSION Using the SITA-S, the Anderson criteria showed a high positive rate in eyes with suspected early GVFDs.