And the Effects on the Downstream Signaling

pathways of FcgRIIa favor an intracellular mechanism for 12-LOX either directly through PLCg2 or via an upstream ITAM signaling complex (see figure). What is important is that this is the first demonstration that 12-LOX is involved in platelet activation through the immune Fc receptor FcgRIIa and as such may provide a viable therapeutic target for patients… CONTINUE READING