Ancistroheynine B and two further 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus heyneanus Wall.

@article{Bringmann2004AncistroheynineBA,
  title={Ancistroheynine B and two further 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus heyneanus Wall.},
  author={Gerhard Bringmann and Michael Dreyer and Manuela Michel and Francis S.K. Tayman and Reto Brun},
  journal={Phytochemistry},
  year={2004},
  volume={65 21},
  pages={
          2903-7
        }
}
A new axially chiral naphthylisoquinoline alkaloid, ancistroheynine B (7), has been isolated from the leaves of the Indian liana Ancistrocladus heyneanus Wall., along with two known related alkaloids, ancistrocladidine (3) and ancistrotanzanine C (6), which are 7,3'-coupled, too. The structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods. Biological activities of ancistroheynine B against the pathogens of malaria, leishmaniasis, Chagas' disease, and African… Expand
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TLDR
Ancistroheynine A is the first 7,8′-coupled naphthylisoquinoline alkaloid found in A. heyneanus and displays pronounced in vitro activity against Plasmodium falciparum, the most lethal human malaria parasite. Expand
Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis.
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Two new 5,8‘-coupled naphthylisoquinoline alkaloid alkaloids have been isolated from Ancistrocladus ealaensis and exhibited activity against Leishmania donovani and Trypanosoma cruzi in vitro. Expand
Ancisheynine, a novel naphthylisoquinolinium alkaloid from Ancistrocladus heyneanus
A novel naphthylisoclumoline alkaloid, ancisheynine 1, was isolated from the aerial part of Ancistrocladus heyneanus Wallich ex J. Graham (Ancistrocladaceae). Ancisheynine 1 contained a previouslyExpand
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From the as yet unexplored East African Liana, Ancistrocladus robertsoniorum, several naphthylisoquinoline alkaloids have been isolated, based mainly on High Speed Countercurrent ChromatographyExpand
Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis.
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The structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods and the biological activities of the alkaloids against the pathogens causing malaria tropica, leishmaniasis, Chagas' disease, and African sleeping sickness were evaluated. Expand
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The results demonstrate that naphthylisoquinoline alkaloids constitute an interesting novel class of antitrypanosomal compounds worth further optimization. Expand
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Evidence for the absolute configuration of ancistrocladisine[(3S,7R)-7-(4,5-dimethoxy-2-methyl-1-naphthyl)-3,4-dihydro-6,8-dimethoxy-1,3-dimethylisoquinoline](1) and ancistrocladidineExpand
Nmr spectroscopic analysis of ancistrocladidine
Abstract The first unambiguous assignment of the 1 H and 13 C NMR spectra of a member of the naphthaleneisoquinoline series of alkaloids, the 7,3′-linked compound ancistrocladidine, has been achievedExpand
3D QSAR Investigations on Antimalarial Naphthylisoquinoline Alkaloids by Comparative Molecular Similarity Indices Analysis (CoMSIA), Based on Different Alignment Approaches
TLDR
3D QSAR models based on the CoMSIA descriptor fields were established using a diverse data set of 53 antimalarial biaryl compounds, resulting in interesting conclusions about the effects of particular functional groups on the biological activity and will now guide the design of novel, hopefully even more active compounds. Expand
Naphthylisoquinoline alkaloids against malaria: evaluation of the curative potentials of dioncophylline C and dioncopeltine A against Plasmodium berghei in vivo
TLDR
The naphthylisoquinoline alkaloid alkaloids are promising new antimalarial agents and are shown to exhibit antiparasitic activity in Plasmodium berghei-infected mice. Expand
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