Ancient human genomics: the methodology behind reconstructing evolutionary pathways.

@article{Marciniak2015AncientHG,
  title={Ancient human genomics: the methodology behind reconstructing evolutionary pathways.},
  author={Stephanie Marciniak and Jennifer Klunk and Alison M. Devault and Jacob M. Enk and Hendrik N Poinar},
  journal={Journal of human evolution},
  year={2015},
  volume={79},
  pages={
          21-34
        }
}
High-throughput sequencing (HTS) has radically altered approaches to human evolutionary research. Recent contributions highlight that HTS is able to reach depths of the human lineage previously thought to be impossible. In this paper, we outline the methodological advances afforded by recent developments in DNA recovery, data output, scalability, speed, and resolution of the current sequencing technology. We review and critically evaluate the 'DNA pipeline' for ancient samples: from DNA… CONTINUE READING
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