Ancient human genome sequence of an extinct Palaeo-Eskimo

@article{Rasmussen2010AncientHG,
  title={Ancient human genome sequence of an extinct Palaeo-Eskimo},
  author={M. Rasmussen and Yingrui Li and Stinus Lindgreen and J. S. Pedersen and A. Albrechtsen and I. Moltke and M. Metspalu and E. Metspalu and T. Kivisild and Ramneek Gupta and M. Bertalan and Kasper Nielsen and M. Gilbert and Yong Wang and M. Raghavan and P. Campos and Hanne Munkholm Kamp and Andrew S. Wilson and A. Gledhill and S. Tridico and M. Bunce and E. Lorenzen and Jonas Binladen and Xiaosen Guo and J. Zhao and Xiuqing Zhang and H. Zhang and Zhuo Li and Minfeng Chen and L. Orlando and K. Kristiansen and M. Bak and N. Tommerup and C. Bendixen and T. Pierre and B. Gr{\o}nnow and M. Meldgaard and C. Andreasen and S. Fedorova and L. Osipova and T. Higham and C. Ramsey and T. V. Hansen and F. Nielsen and M. Crawford and S. Brunak and T. Sicheritz-Pont{\'e}n and R. Villems and R. Nielsen and A. Krogh and J. Wang and E. Willerslev},
  journal={Nature},
  year={2010},
  volume={463},
  pages={757-762}
}
We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw… Expand
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