Ancient hepatitis B viruses from the Bronze Age to the Medieval period

  title={Ancient hepatitis B viruses from the Bronze Age to the Medieval period},
  author={Barbara M{\"u}hlemann and Terry C. Jones and Peter de Barros Damgaard and Morten E. Allentoft and I. Shevnina and A. Logvin and E. Usmanova and Irina P. Panyushkina and B. Boldgiv and Tsevel Bazartseren and Kadicha Tashbaeva and Victor Merz and Nina Lau and V. Smr{\vc}ka and Dmitry Voyakin and E. Kitov and A. Epimakhov and Dalia D. Pokutta and M. Vicze and T. D. Price and V. Moiseyev and Anders J. Hansen and L. Orlando and S. Rasmussen and M. Sikora and L. Vinner and A. Osterhaus and D. Smith and D. Glebe and R. Fouchier and C. Drosten and Karl-G{\"o}ran Sj{\"o}gren and Kristian Kristiansen and E. Willerslev},
  • Barbara Mühlemann, Terry C. Jones, +31 authors E. Willerslev
  • Published 2018
  • Biology, Medicine
  • Nature
  • Hepatitis B virus (HBV) is a major cause of human hepatitis. There is considerable uncertainty about the timescale of its evolution and its association with humans. Here we present 12 full or partial ancient HBV genomes that are between approximately 0.8 and 4.5 thousand years old. The ancient sequences group either within or in a sister relationship with extant human or other ape HBV clades. Generally, the genome properties follow those of modern HBV. The root of the HBV tree is projected to… CONTINUE READING
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