Ancient Homology of the Mitochondrial Contact Site and Cristae Organizing System Points to an Endosymbiotic Origin of Mitochondrial Cristae

@article{MuozGmez2015AncientHO,
  title={Ancient Homology of the Mitochondrial Contact Site and Cristae Organizing System Points to an Endosymbiotic Origin of Mitochondrial Cristae},
  author={Sergio A Mu{\~n}oz-G{\'o}mez and Claudio H Slamovits and Joel B Dacks and Kaitlyn A. Baier and Katelyn D. Spencer and Jeremy G Wideman},
  journal={Current Biology},
  year={2015},
  volume={25},
  pages={1489-1495}
}
Mitochondria are eukaryotic organelles that originated from an endosymbiotic α-proteobacterium. As an adaptation to maximize ATP production through oxidative phosphorylation, mitochondria contain inner membrane invaginations called cristae. Recent work has characterized a multi-protein complex in yeast and animal mitochondria called MICOS (mitochondrial contact site and cristae organizing system), responsible for the determination and maintenance of cristae [1-4]. However, the origin and… CONTINUE READING
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