Anchorless Prion Protein Results in Infectious Amyloid Disease Without Clinical Scrapie

  title={Anchorless Prion Protein Results in Infectious Amyloid Disease Without Clinical Scrapie},
  author={B. Chesebro and M. Trifilo and R. Race and Kimberly D. Meade-White and C. Teng and R. Lacasse and L. Raymond and C. Favara and G. Baron and S. Priola and B. Caughey and E. Masliah and M. Oldstone},
  pages={1435 - 1439}
  • B. Chesebro, M. Trifilo, +10 authors M. Oldstone
  • Published 2005
  • Biology, Medicine
  • Science
  • In prion and Alzheimer's diseases, the roles played by amyloid versus nonamyloid deposits in brain damage remain unresolved. In scrapie-infected transgenic mice expressing prion protein (PrP) lacking the glycosylphosphatidylinositol (GPI) membrane anchor, abnormal protease-resistant PrPres was deposited as amyloid plaques, rather than the usual nonamyloid form of PrPres. Although PrPres amyloid plaques induced brain damage reminiscent of Alzheimer's disease, clinical manifestations were minimal… CONTINUE READING
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