Anchoring the genome

  title={Anchoring the genome},
  author={Diego Ottaviani and Elliott Lever and Petros Takousis and Denise Sheer},
  journal={Genome Biology},
  pages={201 - 201}
Although the principles governing chromosomal architecture are largely unresolved, there is evidence that higher-order chromatin folding is mediated by the anchoring of specific DNA sequences to the nuclear matrix. These genome anchors are also crucial regulators of gene expression and DNA replication, and play a role in pathogenesis.