Anchoring of a monotopic membrane protein: the binding of prostaglandin H2 synthase-1 to the surface of a phospholipid bilayer

@article{Nina2000AnchoringOA,
  title={Anchoring of a monotopic membrane protein: the binding of prostaglandin H2 synthase-1 to the surface of a phospholipid bilayer},
  author={M. Nina and S. Bern{\`e}che and B. Roux},
  journal={European Biophysics Journal},
  year={2000},
  volume={29},
  pages={439-454}
}
  • M. Nina, S. Bernèche, B. Roux
  • Published 2000
  • Chemistry, Medicine
  • European Biophysics Journal
  • Abstract Prostaglandin H2 synthases (PGHS-1 and -2) are monotopic peripheral membrane proteins that catalyse the synthesis of prostaglandins in the arachidonate cascade. Picot et al. (1994) proposed that the enzyme is anchored to one leaflet of the bilayer by a membrane anchoring domain consisting of a right-handed spiral of amphipathic helices (residues 73–116) forming a planar motif. Two different computational approaches are used to examine the association of the PGHS-1 membrane anchoring… CONTINUE READING
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