Anchoring junctions as drug targets: role in contraceptive development.

@article{Mruk2008AnchoringJA,
  title={Anchoring junctions as drug targets: role in contraceptive development.},
  author={Dolores D. Mruk and Bruno Silvestrini and C. Yan Cheng},
  journal={Pharmacological reviews},
  year={2008},
  volume={60 2},
  pages={
          146-80
        }
}
In multicellular organisms, cell-cell interactions are mediated in part by cell junctions, which underlie tissue architecture. Throughout spermatogenesis, for instance, preleptotene leptotene spermatocytes residing in the basal compartment of the seminiferous epithelium must traverse the blood-testis barrier to enter the adluminal compartment for continued development. At the same time, germ cells must also remain attached to Sertoli cells, and numerous studies have reported extensive… CONTINUE READING
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