Anchoring junctions as drug targets: role in contraceptive development.

  title={Anchoring junctions as drug targets: role in contraceptive development.},
  author={Dolores D. Mruk and Bruno Silvestrini and C. Yan Cheng},
  journal={Pharmacological reviews},
  volume={60 2},
In multicellular organisms, cell-cell interactions are mediated in part by cell junctions, which underlie tissue architecture. Throughout spermatogenesis, for instance, preleptotene leptotene spermatocytes residing in the basal compartment of the seminiferous epithelium must traverse the blood-testis barrier to enter the adluminal compartment for continued development. At the same time, germ cells must also remain attached to Sertoli cells, and numerous studies have reported extensive… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 548 references

Association of extracellular cleavage of E-cadherin mediated by MMP-7 with HGF-induced in vitro invasion in human stomach cancer cells.

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes • 2007
View 24 Excerpts
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Plakophilins: Multifunctional proteins or just regulators of desmosomal adhesion?

Biochimica et biophysica acta • 2007
View 5 Excerpts
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Drug Insight: recent advances in male hormonal contraception

Nature Clinical Practice Endocrinology &Metabolism • 2006
View 5 Excerpts
Highly Influenced