Anchorage dependence of mitogen-induced G1 to S transition in primary T lymphocytes.

  title={Anchorage dependence of mitogen-induced G1 to S transition in primary T lymphocytes.},
  author={Jens Geginat and Giovanna Bossi and Jeffrey R Bender and Ruggero Pardi},
  journal={Journal of immunology},
  volume={162 9},
Anchorage dependence defines the cellular requirement for integrin-mediated adhesion to substrate to initiate DNA replication in response to growth factors. In this study we investigated whether normal T cells, which spend extended periods in a nonadherent state, show similar requirements for cell cycle progression in response to TCR stimulation. Resting primary T lymphocytes were induced to enter the cell cycle by TCR triggering, and leukocyte integrins were either engaged using purified ICAM… CONTINUE READING

From This Paper

Figures and tables from this paper.


Publications citing this paper.
Showing 1-10 of 14 extracted citations


Publications referenced by this paper.
Showing 1-10 of 53 references

A p 38 MAP kinase inhibitor SB 203580 inhibits CD 28 - dependent T cell proliferation and IL - 2 production

  • R Treisman
  • Biochem . Soc . Trans .
  • 1997

Similar Papers

Loading similar papers…