Ancestry of neuronal monoamine transporters in the Metazoa.

  title={Ancestry of neuronal monoamine transporters in the Metazoa.},
  author={Stanley Caveney and Wendy Cladman and LouAnn Verellen and Cam Donly},
  journal={The Journal of experimental biology},
  volume={209 Pt 24},
Selective Na(+)-dependent re-uptake of biogenic monoamines at mammalian nerve synapses is accomplished by three types of solute-linked carrier family 6 (SLC6) membrane transporter with high affinity for serotonin (SERTs), dopamine (DATs) and norepinephrine (NETs). An additional SLC6 monoamine transporter (OAT), is responsible for the selective uptake of the phenolamines octopamine and tyramine by insect neurons. We have characterized a similar high-affinity phenoloamine transporter expressed in… CONTINUE READING