Ancestry-independent fate specification and plasticity in the developmental timing of a typical Drosophila neuronal lineage.

@article{Gaziova2009AncestryindependentFS,
  title={Ancestry-independent fate specification and plasticity in the developmental timing of a typical Drosophila neuronal lineage.},
  author={Ivana Gaziova and Krishna Moorthi Bhat},
  journal={Development},
  year={2009},
  volume={136 2},
  pages={263-74}
}
In the Drosophila CNS, combinatorial, interdependent, sequential genetic programs in neuroectodermal (NE) cells, prior to the formation of neuroblasts (NBs), determine the initial identity of NBs. Temporal factors are then sequentially expressed to change the temporal identity. It is unclear at what levels this positional and temporal information integrates to determine progeny cell identity. One idea is that this is a top-down linear process: the identity of a NB determines the identity of its… CONTINUE READING
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