Ancestry explains the blunted ventilatory response to sustained hypoxia and lower exercise ventilation of Quechua altitude natives.

@article{Brutsaert2005AncestryET,
  title={Ancestry explains the blunted ventilatory response to sustained hypoxia and lower exercise ventilation of Quechua altitude natives.},
  author={Tom D. Brutsaert and Esteban J. Parra and Mark D. Shriver and Alfredo Gamboa and Maria C Rivera-Ch and Fabiola L{\'e}on-Velarde},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2005},
  volume={289 1},
  pages={R225-34}
}
Andean high-altitude (HA) natives have a low (blunted) hypoxic ventilatory response (HVR), lower effective alveolar ventilation, and lower ventilation (VE) at rest and during exercise compared with acclimatized newcomers to HA. Despite blunted chemosensitivity and hypoventilation, Andeans maintain comparable arterial O(2) saturation (Sa(O(2))). This study was designed to evaluate the influence of ancestry on these trait differences. At sea level, we measured the HVR in both acute (HVR-A) and… CONTINUE READING

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