Ancestry as a determinant of mean population C-reactive protein values: implications for cardiovascular risk prediction.

@article{Shah2010AncestryAA,
  title={Ancestry as a determinant of mean population C-reactive protein values: implications for cardiovascular risk prediction.},
  author={Tina P Shah and Paul Newcombe and Liam Smeeth and Juliet Addo and Juan P. Casas and J. Whittaker and Michelle Avril Miller and Lorna E. Tinworth and S Horsburgh Jeffery and Pasquale Strazzullo and Francesco P Cappuccio and Aroon D. Hingorani},
  journal={Circulation. Cardiovascular genetics},
  year={2010},
  volume={3 5},
  pages={
          436-44
        }
}
BACKGROUND Eligibility for rosuvastatin treatment for cardiovascular disease prevention includes a C-reactive protein (CRP) concentration >2 mg/L. Most observational studies of CRP and cardiovascular disease have been in Europeans. We evaluated the influence of ancestry on population CRP concentration to assess the implications for statin targeting in non-Europeans. METHODS AND RESULTS In a systematic review and meta-analysis among 221 287 people from 89 studies, geometric mean CRP was 2.6 mg… CONTINUE READING

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