Ancestral proportions and their association with skin pigmentation and bone mineral density in Puerto Rican women from New York city

  title={Ancestral proportions and their association with skin pigmentation and bone mineral density in Puerto Rican women from New York city},
  author={Carolina Bonilla and Mark David Shriver and Esteban Juan Parra and Alfredo Jones and Jos{\'e} R. Fern{\'a}ndez},
  journal={Human Genetics},
Hispanic and African American populations exhibit an increased risk of obesity compared with populations of European origin, a feature that may be related to inherited risk alleles from Native American and West African parental populations. However, a relationship between West African ancestry and obesity-related traits, such as body mass index (BMI), fat mass (FM), and fat-free mass (FFM), and with bone mineral density (BMD) in African American women has only recently been reported. In order… 

Genetic admixture and body composition in Puerto Rican adults from the Boston Puerto Rican Osteoporosis Study

The relationship between genetic admixture and body composition in Puerto Ricans from the Boston Puerto Rican Osteoporosis Study is investigated to contribute to understanding of the high prevalence of chronic disease experienced by this population and has implications for other ethnic minority groups, particularly those with multiple ancestries.

African genetic admixture is associated with body composition and fat distribution in a cross-sectional study of children

It is demonstrated that ancestral genetic background contributes to racial/ethnic differences in body composition above and beyond the effects of racial/ ethnic classification and suggest a genetic contribution to total body fat accumulation, abdominal adiposity, LM and BMC.

The relationship between European genetic admixture and body composition among Hispanics and Native Americans

This study examines the relationship between genetic admixture and two phenotypic measurements that are potentially related to health: body mass index (BMI) and percent body fat (PBF) in Hispanics and Native Americans and compares the findings to previous research.

Implications of correlations between skin color and genetic ancestry for biomedical research

The results demonstrate the utility of ancestry-informative genetic markers and admixture methods and emphasize the need to be cautious when using pigmentation as a proxy of ancestry or when extrapolating the results from one admixed population to another.

Adiposity and genetic admixture, but not race/ethnicity, influence bone mineral content in peripubertal children

It is suggested that genetic admixture and percent body fat, but not race/ethnicity, diet, or physical activity, influence BMC in the authors' sample of peripubertal children.

Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women

It is suggested that genetic admixture may influence the etiology of lipid metabolism-related diseases and obesity in elderly women.

The role of country of birth, and genetic and self-identified ancestry, in obesity susceptibility among African and Hispanic Americans

Being US-born is associated with a substantially higher BMI and risk of obesity in both men and women and genetic ancestry, but not self-reported ancestry, isassociated with obesity susceptibility, but only among US- born women in this New York–based population.

Body Fat and Racial Genetic Admixture Are Associated With Aerobic Fitness Levels in a Multiethnic Pediatric Population

Evaluating the association of adiposity with aerobic fitness using objectively measured levels of percent body fat compared to BMI as a percentile proxy for adiposity while controlling for genetic admixture found differences should be taken into account when evaluating outcomes of health interventions.

Population admixture associated with disease prevalence in the Boston Puerto Rican health study

The genetic ancestry of 1,129 subjects from the Boston Puerto Rican Health Study was estimated based on genotypes of 100 ancestry informative markers (AIMs) and the effects of ancestry on tests of association between single AIMs and disease traits were examined.

Biogeographic ancestry, self-identified race, and admixture-phenotype associations in the Heart SCORE Study.

For most nongenetic cardiovascular epidemiology studies, SIR is sufficient for predicting CVD risk factor differences between European Americans and African Americans, however, higher body mass index and diastolic blood pressure were significantly associated with West African BGA among African American, suggesting that BGA should be considered in genetic cardiovascular epidemiological studies carried out among African Americans.



Variations in Bone Density among Persons of African Heritage

Heterogeneity among different ethnic groups of African heritage may provide an opportunity for research to better explain race-specific differences in bone metabolism.

Association of African genetic admixture with resting metabolic rate and obesity among women.

Results provide evidence supporting the application of admixture mapping methods to the identification of genes that result in higher levels of obesity among African-American women.

Skin pigmentation, biogeographical ancestry and admixture mapping

This work indicates that it is possible to estimate the individual ancestry of a person based on DNA analysis with a reasonable number of well-defined genetic markers, as well as applying two methods of admixture mapping to test for the effects of three candidate genes.

Prevalence of Diabetes in Mexican Americans: Relationship to Percent of Gene Pool Derived from Native American Sources

The association of genetic admixture with NIDDM rates suggests that much of the epidemic of NID DM in Mexican Americans is confined to that part of the population with a substantial native American heritage.

Comparisons for body mass index and body fat percent among Puerto Ricans, blacks, whites and Asians living in the New York City area.

Puerto Ricans had the largest BMI and the largest percent of subjects with body weight more than 120% of their ideal weight, and the smallest fat percent of the four ethnic groups, while Asians had the smallest BMI, but 63% of them had fat percent above the median values for whites in each gender.

Ethnic Differences in the Risk of Type 2 Diabetes Attributable to Differences in Abdominal Adiposity in American Women

  • I. Okosun
  • Medicine
    Journal of cardiovascular risk
  • 2000
Objective To determine how much of the relative difference in the risk of type 2 diabetes between White and non-White (Black and Hispanic) American women can be explained by differences in the

Diabetes, gallbladder disease, obesity, and hypertension among Hispanics in New Mexico.

The similar epidemiology of these diseases in the Hispanics of New Mexico and the Mexican Americans of Texas supports the hypothesis that American Indian admixture underlies the development of these conditions in Hispanics throughout the Southwest.

CYP3A4-V and prostate cancer in African Americans: causal or confounding association because of population stratification?

The results reveal the potential for confounding of association studies by using African Americans and the need for study designs that take into account substructure caused by differences in ancestral proportions between cases and controls.

Individual estimates of European genetic admixture associated with lower body-mass index, plasma glucose, and prevalence of type 2 diabetes in Pima Indians.

In nondiabetic Pimans, multivariate linear regressions of quantitative predictors of type 2 diabetes mellitus, including fasting plasma glucose, 2-h post-load Plasma glucose, and body-mass index, showed significant inverse relations with IA, illustrating the ongoing evolution of populations by the mechanism of gene flow and its effect on disease risk in the groups with admixture.

Estimating African American admixture proportions by use of population-specific alleles.

Significant nonrandom association between two markers located 22 cM apart (FY-null and AT3) is detected, most likely due to admixture linkage disequilibrium created in the interbreeding of the two parental populations, emphasize the importance of admixed populations as a useful resource for mapping traits with different prevalence in two parental population.