Ancestral genomic contributions to complex traits in contemporary Europeans

@article{Marnetto2022AncestralGC,
  title={Ancestral genomic contributions to complex traits in contemporary Europeans},
  author={Davide Marnetto and Vasili Pankratov and Mayukh Mondal and Francesco Montinaro and Katri P{\"a}rna and Leonardo Vallini and Ludovica Molinaro and Lehti Saag and Liisa Loog and Sara Montagnese and Rodolfo Costa and Mait Metspalu and Anders Eriksson and Luca Pagani},
  journal={Current Biology},
  year={2022},
  volume={32},
  pages={1412-1419.e3}
}
1 Citations

1,000 ancient genomes uncover 10,000 years of natural selection in Europe

The assembled genome-wide data from Europe over 10,000 years is assembled, providing a dataset that is large enough to resolve the timing of selection into the Neolithic, Bronze Age, and Historical periods and highlights the unique power of ancient DNA in elucidating biological change that accompanied the profound cultural transformations of recent human history.

References

SHOWING 1-10 OF 40 REFERENCES

Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European

An approximately 7,000-year-old Mesolithic skeleton discovered at the La Braña-Arintero site in León, Spain, is sequenceed to retrieve a complete pre-agricultural European human genome, providing evidence that a significant number of derived, putatively adaptive variants associated with pathogen resistance in modern Europeans were already present in this hunter-gatherer.

Human adaptation and population differentiation in the light of ancient genomes

Modern and ancient genomic data are combined in a simple statistic to time allele frequency changes, and evidence for a role of local adaptation in human population differentiation is provided.

Genome-wide patterns of selection in 230 ancient Eurasians

A genome-wide scan for selection using ancient DNA is reported, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 bc, including 163 with newly reported data.

Differences in local population history at the finest level: the case of the Estonian population

The history of human populations within the last few millennia can be highly region specific and cannot be properly studied without taking local genetic structure into account, and a framework for relating effective population size estimated from genetic data to actual census size is provided.

Ancient human genomes suggest three ancestral populations for present-day Europeans

It is shown that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians; and early European farmers, who were mainly of Near Eastern origin but also harboured west Europeanhunter-gatherer related ancestry.

Genetic contributions to variation in human stature in prehistoric Europe

It is shown that changes over the past 35,000 y are largely predicted by genetics but also identify specific shifts that are more likely to be environmentally driven, and how these can be combined with phenotypic measurements to understand the relative contribution of genetic and developmentally plastic responses to environmental change.

Reconstructing Indian Population History

It is predicted that there will be an excess of recessive diseases in India, which should be possible to screen and map genetically and is higher in traditionally upper caste and Indo-European speakers.

The Genomic Health of Ancient Hominins

The overall genomic health of the Altai Neandertal is worse than 97% of present-day humans and that Ötzi, the Tyrolean Iceman, had a genetic predisposition for gastrointestinal and cardiovascular diseases.

A Population Genetic Signal of Polygenic Adaptation

This analysis uncovers a number of putative signals of local adaptation, and develops methods for detecting unusually strong correlations between genetic values and specific environmental variables, as well as a generalization of comparisons to test for over-dispersion of genetic values among populations.

Genetic ancestry changes in Stone to Bronze Age transition in the East European plain

Genetic analysis of genome-wide sequence data from 30 individuals from the understudied western part of present-day Russia shows that Eastern hunter-gatherer ancestry was present in northwestern Russia already from around 10,000 BCE, and sees a change in ancestry with the arrival of farming.