Ancestral antibiotic resistance in Mycobacterium tuberculosis.

  title={Ancestral antibiotic resistance in Mycobacterium tuberculosis.},
  author={Rowan P. Morris and Liem Nguyen and John Gatfield and Kevin C. Visconti and Kien Nguyen and Dirk Schnappinger and Sabine Ehrt and Yang Liu and Leonid B Heifets and Jean Pieters and Gary K. Schoolnik and Charles B. Thompson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 34},
Chemotherapeutic options to treat tuberculosis are severely restricted by the intrinsic resistance of Mycobacterium tuberculosis to the majority of clinically applied antibiotics. Such resistance is partially provided by the low permeability of their unique cell envelope. Here we describe a complementary system that coordinates resistance to drugs that have penetrated the envelope, allowing mycobacteria to tolerate diverse classes of antibiotics that inhibit cytoplasmic targets. This system… CONTINUE READING
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