Ancestral TCDD exposure promotes epigenetic transgenerational inheritance of imprinted gene Igf2: Methylation status and DNMTs.

@article{Ma2015AncestralTE,
  title={Ancestral TCDD exposure promotes epigenetic transgenerational inheritance of imprinted gene Igf2: Methylation status and DNMTs.},
  author={Jing Ma and Xi Chen and Yanan Liu and Qunhui Xie and Yawen Sun and Jingshan Chen and Ling Leng and Huan Yan and Bin Zhao and N J Tang},
  journal={Toxicology and applied pharmacology},
  year={2015},
  volume={289 2},
  pages={193-202}
}
Ancestral TCDD exposure could induce epigenetic transgenerational phenotypes, which may be mediated in part by imprinted gene inheritance. The aim of our study was to evaluate the transgenerational effects of ancestral TCDD exposure on the imprinted gene insulin-like growth factor-2 (Igf2) in rat somatic tissue. TCDD was administered daily by oral gavage to groups of F0 pregnant SD rats at dose levels of 0 (control), 200 or 800 ng/kg bw during gestation day 8-14. Animal transgenerational model… CONTINUE READING

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4 Excerpts

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