Ancestral Regulatory Circuits Governing Ectoderm Patterning Downstream of Nodal and BMP2/4 Revealed by Gene Regulatory Network Analysis in an Echinoderm

@inproceedings{Saudemont2010AncestralRC,
  title={Ancestral Regulatory Circuits Governing Ectoderm Patterning Downstream of Nodal and BMP2/4 Revealed by Gene Regulatory Network Analysis in an Echinoderm},
  author={Alexandra Saudemont and Emmanuel Haillot and Flavien Mekpoh and Nathalie Bessodes and Magali Quirin and François Lapraz and V{\'e}ronique Duboc and Eric R{\"o}ttinger and R. Michael Range and Arnaud Oisel and Lydia Besnardeau and Patrick Wincker and Thierry Lepage},
  booktitle={PLoS genetics},
  year={2010}
}
Echinoderms, which are phylogenetically related to vertebrates and produce large numbers of transparent embryos that can be experimentally manipulated, offer many advantages for the analysis of the gene regulatory networks (GRN) regulating germ layer formation. During development of the sea urchin embryo, the ectoderm is the source of signals that pattern all three germ layers along the dorsal-ventral axis. How this signaling center controls patterning and morphogenesis of the embryo is not… CONTINUE READING
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