Anatomy of the estrogen response element.

  title={Anatomy of the estrogen response element.},
  author={Christian J. Gruber and Doris M. Gruber and Isabel Marieluise Gruber and Fritz Wieser and Johannes C. Huber},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={15 2},
Estrogens exert their regulatory potential on gene expression through different nuclear and non-nuclear mechanisms. A direct nuclear approach is the interaction of estrogen with specific target sequences of DNA, estrogen response elements (ERE) or units. EREs can be grouped into perfect and imperfect palindromic sequences with the imperfect sequences differing from the consensus sequence in one or more nucleotides and being less responsive to the activated estrogen-estrogen receptor (ER… CONTINUE READING
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