Anatomy of protein structures: visualizing how a one-dimensional protein chain folds into a three-dimensional shape.

@article{Tsai2000AnatomyOP,
  title={Anatomy of protein structures: visualizing how a one-dimensional protein chain folds into a three-dimensional shape.},
  author={C. J. Tsai and Jacob V. Maizel and Ruth Nussinov},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 22},
  pages={12038-43}
}
Here, we depict the anatomy of protein structures in terms of the protein folding process. Via an iterative, top-down dissecting procedure, tertiary structures are spliced down to reveal their anatomy: first, to produce domains (defined by visual three-dimensional inspection criteria); then, hydrophobic folding units (HFU); and, at the end of a multilevel process, a set of building blocks. The resulting anatomy tree organization not only clearly depicts the organization of a one-dimensional… CONTINUE READING

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