Anatomy of germinal centers in mouse spleen, with special reference to "follicular dendritic cells"

@article{Chen1978AnatomyOG,
  title={Anatomy of germinal centers in mouse spleen, with special reference to "follicular dendritic cells"},
  author={Ling Ling Chen and Joe C. Adams and Ralph Marvin Steinman},
  journal={The Journal of Cell Biology},
  year={1978},
  volume={77},
  pages={148 - 164}
}
Lymphocyte proliferation in germinal centers (GC's) is thought to be triggered by antigen retained extracellularly on the surface of special "dendritic" cells. The anatomy and function of these cells have not been studied directly or in detail. We therefore examined mouse spleen GC's developing in response to sheep erythrocyte stimulation. We found that distincitve "follicular dendritic cells" (FDC's) were present in both the GC and adjacent mantle region of secondary follicles. The large… CONTINUE READING