Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase.

@article{Iqbal2009AnatomyOA,
  title={Anatomy of a simple acyl intermediate in enzyme catalysis: combined biophysical and modeling studies on ornithine acetyl transferase.},
  author={Aman Iqbal and Ian J. Clifton and Maria Bagonis and Nadia J. Kershaw and Carmen Domene and Timothy D W Claridge and Christopher W. Wharton and Christopher J. Schofield},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 2},
  pages={749-57}
}
Acyl-enzyme complexes are intermediates in reactions catalyzed by many hydrolases and related enzymes which employ nucleophilic catalysis. However, most of the reported structural data on acyl-enzyme complexes has been acquired under noncatalytic conditions. Recent IR analyses have indicated that some acyl-enzyme complexes may be more flexible than most crystallographic analyses have implied. OAT2 is a member of the N-terminal nucleophile (Ntn) hydrolase enzyme superfamily and catalyzes the… CONTINUE READING

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