Anatomy of CD1–lipid antigen complexes

  title={Anatomy of CD1–lipid antigen complexes},
  author={D. Branch Moody and Dirk M. Zajonc and Ian A. Wilson},
  journal={Nature Reviews Immunology},
CD1 proteins bind lipids to form antigen complexes that contact T-cell receptors and activate T cells. Recent crystal structures of CD1 proteins show that their antigen-binding grooves are composed of up to four pockets (A′, C′, F′ and T′) and two antigen portals (C′ and F′). Although certain structural features are conserved among CD1 proteins, the grooves of CD1a, CD1b and CD1d differ in the number, shape and connectivity of their antigen-binding pockets. Here, we outline how the portals and… CONTINUE READING

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Molecular mechanism of lipopeptide presentation by CD1a

  • Zajonc, M D.
  • Immunity 22,
  • 2005

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