Anatomy and physiology of the blood-brain barrier.

  title={Anatomy and physiology of the blood-brain barrier.},
  author={Yonatan Serlin and Ilan Shelef and Boris Knyazer and Alon Friedman},
  journal={Seminars in cell & developmental biology},
Essential requisite for the preservation of normal brain activity is to maintain a narrow and stable homeostatic control in the neuronal environment of the CNS. Blood flow alterations and altered vessel permeability are considered key determinants in the pathophysiology of brain injuries. We will review the present-day literature on the anatomy, development and physiological mechanisms of the blood-brain barrier, a distinctive and tightly regulated interface between the CNS and the peripheral… CONTINUE READING