Anatomy and physiology in delivery: can we define our targets?

@article{Chrystyn1999AnatomyAP,
  title={Anatomy and physiology in delivery: can we define our targets?},
  author={Henry Chrystyn},
  journal={Allergy},
  year={1999},
  volume={54 Suppl 49},
  pages={
          82-7
        }
}
Studies have shown that the receptors for beta-agonists, inflammatory markers, and mast cells are distributed throughout the airways. Thus topical delivery of drug for the management of asthma requires an even spread throughout the lungs. Particles of 2-5 microm in diameter have the greatest potential to be deposited throughout the lungs during inhalation, by impaction and sedimentation. Inhaled products, therefore, are formulated such that almost half of the dose emitted during inhalation… CONTINUE READING

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