Anatomy and neurophysiology of pruritus.

  title={Anatomy and neurophysiology of pruritus.},
  author={Akihiko Ikoma and Ferda Cevikbas and Cordula Kempkes and Martin Steinhoff},
  journal={Seminars in cutaneous medicine and surgery},
  volume={30 2},
Itch has been described for many years as an unpleasant sensation that evokes the urgent desire to scratch. Studies of the neurobiology, neurophysiology, and cellular biology of itch have gradually been clarifying the mechanism of itch both peripherally and centrally. The discussion has been focused on which nerves and neuroreceptors play major roles in itch induction. The "intensity theory" hypothesizes that signal transduction on the same nerves leads to either pain (high intensity) or itch… CONTINUE READING
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