Anatomofunctional organization of the insular cortex: A study using intracerebral electrical stimulation in epileptic patients

@article{Afif2010AnatomofunctionalOO,
  title={Anatomofunctional organization of the insular cortex: A study using intracerebral electrical stimulation in epileptic patients},
  author={Afif Afif and Lorella Minotti and Philippe Kahane and Dominique Hoffmann},
  journal={Epilepsia},
  year={2010},
  volume={51}
}
Purpose:  Different lines of evidence suggest that the insular cortex has many important functional roles. Direct electrical stimulation (ES) of the human insular cortex during surgical procedures for epilepsy, functional imaging techniques, and lesion studies also occasionally induces clinical responses. 

Somatosensory Thalamic Activity Modulation by Posterior Insular Stimulation: Cues to Clinical Application Based on Comparison of Frequencies in a Cat Model

The posterior insula (PI) has been proposed as a potential neurostimulation target for neuropathic pain relief as it represents a key‐structure in pain processing. However, currently available data

Functional connectivity of insular efferences

The aim of this study was to explore the functional connectivity between the insula and other cortical regions, in human, using cortico‐cortical evoked potentials (CCEPs) to explore Cortico-Cortical Evoked Potential Associations.

Features of somatosensory manifestations induced by intracranial electrical stimulations of the human insula

Electrical Stimulations of the Human Insula: Their Contribution to the Ictal Semiology of Insular Seizures

Symptoms evoked by insular stimulations are multiple, and the occurrence in given seizure of a somatosensory symptom such as pain or of a laryngeal spasm associated with vestibular, auditory, aphasic, or olfacto-gustatory symptoms points to a discharge development in the insular cortex, which is the only cortical region where stimulations demonstrate such a multimodal representation.

BRAIN OCCASIONAL PAPER Stimulation of the human cortex and the experience of pain: Wilder Penfield’s observations revisited

Thanks to the seminal work of Wilder Graves Penfield (1891–1976) at the Montreal Neurological Institute, electrical stimulation is used worldwide to localize the epileptogenic cortex and to map the

The Insula: A Stimulating Island of the Brain

Overall, insular DCS studies converge on the view that the insula is a multimodal functional hub with a fast propagation of information, whose organization helps understand where insular seizures start and how they propagate.
...

References

SHOWING 1-10 OF 90 REFERENCES

Functional Mapping of the Insular Cortex: Clinical Implication in Temporal Lobe Epilepsy

The insular cortex was investigated on electroclinical arguments suggesting the possibility of a perisylvian spread or a rapid multilobar diffusion of the discharges during video EEG.

Middle short gyrus of the insula implicated in speech production: Intracerebral electric stimulation of patients with epilepsy

Purpose:  Different lines of evidence have suggested an involvement of the insular cortex in speech production. These have included results from lesion studies, functional imaging techniques, and

Cardiovascular effects of human insular cortex stimulation

This work believes this to be the first demonstration of cardiovascular changes elicitable during insular stimulation in humans, and of lateralization of such responses for a cortical site, and may be of relevance in predicting the autonomie effects of stroke in humans and in the explanation of sudden unexpected epileptic death.

Apraxia of speech associated with an infarct in the precentral gyrus of the insula

It is proposed that the precentral gyrus in the left insula is responsible for co-ordination of speech and a paitent with this disturbance showed an acute infarct limited to this region.

Functional anatomy of the human supplementary sensorimotor area: results of extraoperative electrical stimulation.

  • S. LimD. Dinner I. Awad
  • Medicine, Psychology
    Electroencephalography and clinical neurophysiology
  • 1994

Intracerebral low frequency electrical stimulation: a new tool for the definition of the "epileptogenic area"?

Low Frequency (1 Hz) Electrical Stimulation (LFES) has been systematically utilized, during stereo-EEG investigations, in 24 consecutive young adult patients considered for surgical treatment of severe drug-resistant partial epilepsy, to suggest that LFES is of great help for defining the "epileptogenic area".

Nocturnal Hypermotor Seizures, Suggesting Frontal Lobe Epilepsy, Can Originate in the Insula

Summary:  Purpose: To report three patients with drug‐resistant nocturnal hypermotor seizures (NHSs), no detectable brain lesion, and clinically defined nocturnal frontal lobe epilepsy (NFLE) or

[The insula in partial epilepsy].

It could be concluded that the insular cortex is involved in somatic, vegetative and visceral functions to which spontaneous ictal insular symptoms are related and should lead to reconsider the indication of temporal lobectomy and explore directly the ictAL activity of both mesio-temporal and insular cortices before making any decision regarding epilepsy surgery.

Role of Operculoinsular Cortices in Human Pain Processing: Converging Evidence from PET, fMRI, Dipole Modeling, and Intracerebral Recordings of Evoked Potentials

This multimodal study provides cross-validated spatial and temporal information on the pain-related processes occurring in the operculoinsular region, which thus appears as a major site for the early cortical pain encoding in the human brain.
...