Anatomically-distinct genetic associations of APOE ɛ4 allele load with regional cortical atrophy in Alzheimer's disease

@article{Filippini2009AnatomicallydistinctGA,
  title={Anatomically-distinct genetic associations of APOE ɛ4 allele load with regional cortical atrophy in Alzheimer's disease},
  author={Nicola Filippini and Anil Rao and Sally Wetten and Rachel A. Gibson and Michael Borrie and Danilo Guzman and Andrew Kertesz and Inge Loy-English and Julie Williams and Thomas E. Nichols and Brandon J. Whitcher and Paul M. Matthews},
  journal={NeuroImage},
  year={2009},
  volume={44 3},
  pages={724-8}
}
APOE epsilon4 is the best-established genetic risk factor for sporadic Alzheimer's disease (AD). However, while homozygotes show greater disease susceptibility and earlier age of onset than heterozygotes, they may not show faster rates of clinical progression. We hypothesize that there are differential APOE epsilon4 allele-load dependent influences on neuropathology across the brain. Our aim was to define the relationship between APOE epsilon4 allele load and regionally-specific brain cortical… CONTINUE READING