Anatomical studies of DNA fragmentation in rat brain after systemic kainate administration.

@article{Weiss1996AnatomicalSO,
  title={Anatomical studies of DNA fragmentation in rat brain after systemic kainate administration.},
  author={Scott T. Weiss and Oğuz Çataltepe and A. J. Cole},
  journal={Neuroscience},
  year={1996},
  volume={74 2},
  pages={541-51}
}
Rats treated systemically with kainate develop stereotyped epileptic seizures involving mainly limbic structures that may last for hours. This model of limbic status epilepticus has been widely studied using classical neuropathological techniques. We used in situ nick translation histochemistry to examine patterns of DNA fragmentation in this model. We found a stereotyped and reproducible pattern of neuronal populations that demonstrate evidence of DNA fragmentation from 24 h to one week after… CONTINUE READING

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