Anatomical integration of the sacral–hindlimb unit coordinated by GDF11 underlies variation in hindlimb positioning in tetrapods

@article{Matsubara2017AnatomicalIO,
  title={Anatomical integration of the sacral–hindlimb unit coordinated by GDF11 underlies variation in hindlimb positioning in tetrapods},
  author={Yoshiyuki Matsubara and Tatsuya Hirasawa and Shiro Egawa and Ayumi Hattori and Takaya Suganuma and Yuhei Kohara and Tatsuya Nagai and Koji Tamura and Shigeru Kuratani and Atsushi Kuroiwa and Takayuki Suzuki},
  journal={Nature Ecology & Evolution},
  year={2017},
  volume={1},
  pages={1392-1399}
}
Elucidating how body parts from different primordia are integrated during development is essential for understanding the nature of morphological evolution. In tetrapod evolution, while the position of the hindlimb has diversified along with the vertebral formula, the mechanism responsible for this coordination has not been well understood. However, this synchronization suggests the presence of an evolutionarily conserved developmental mechanism that coordinates the positioning of the hindlimb… CONTINUE READING
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