Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression.

@article{BlurtonJones2004AnatomicalEF,
  title={Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression.},
  author={Mathew Blurton-Jones and Pei-fen Kuan and Mark H Tuszynski},
  journal={The Journal of comparative neurology},
  year={2004},
  volume={468 3},
  pages={347-60}
}
Several studies have demonstrated that estrogen modulates brain-derived neurotrophic factor (BDNF) mRNA and protein within the adult hippocampus and cortex. However, mechanisms underlying this regulation are unknown. Although an estrogen response element (ERE)-like sequence has been identified within the BDNF gene, such a classical mechanism of estrogen-induced transcriptional activation requires the colocalized expression of estrogen receptors within cells that produce BDNF. Developmental… CONTINUE READING