Anatomical barriers for antimicrobial agents

  title={Anatomical barriers for antimicrobial agents},
  author={M. Barza},
  journal={European Journal of Clinical Microbiology and Infectious Diseases},
  • M. Barza
  • Published 2006
  • Chemistry, Medicine
  • European Journal of Clinical Microbiology and Infectious Diseases
It is often suggested that there are substantial anatomic barriers to the passage of antibiotics from the circulation into tissues and fluids of the body. In fact, most capillary beds are fenestrated and allow the passage of antimicrobial agents into tissue fluids fairly readily. At equilibrium, the mean concentrations of free (unbound) antibiotic in plasma and tissue fluids over the dosing interval are equal. However, the time to achieve equilibrium may range from minutes to days, depending on… Expand
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