Anatomical and physiological foundations of cerebellar information processing

  title={Anatomical and physiological foundations of cerebellar information processing},
  author={Richard Apps and Martin Garwicz},
  journal={Nature Reviews Neuroscience},
A coordinated movement is easy to recognize, but we know little about how it is achieved. In search of the neural basis of coordination, we present a model of spinocerebellar interactions in which the structure–functional organizing principle is a division of the cerebellum into discrete microcomplexes. Each microcomplex is the recipient of a specific motor error signal — that is, a signal that conveys information about an inappropriate movement. These signals are encoded by spinal reflex… 

Action-based organization and function of cerebellar cortical microcircuits

The results suggest that the cerebellar C3 zone is organized and operates within an action-based frame of reference, with different microcircuits within the zone controlling specific muscle synergies.

The primate cortico-cerebellar system: anatomy and function

  • N. Ramnani
  • Biology, Psychology
    Nature Reviews Neuroscience
  • 2006
The relatively well-developed models of how the cerebellum processes information from the motor cortex might be extended to explain how it could also process information from an area of origin in the cerebral cortex.

On the cerebello-cerebral interactions

  • M. Manto
  • Biology, Psychology
    The Cerebellum
  • 2008
Fundamental questions related to the cerebro-cerebellar networks, such as the modulation of corticomotoneuronal discharges in various contexts, have not been fully addressed, or only indirectly, with recent methods.

Impact of Afferent Inputs on Purkinje Cell Spiking Patterns and Motor Coordination

The effects of alteration in the cerebellar system unraveling the possible role of its afferent inputs are described, which seems to be holding the key to answering both of those questions.

Cerebellar physiology: links between microcircuitry properties and sensorimotor functions

  • H. Jörntell
  • Biology, Psychology
    The Journal of physiology
  • 2017
The cerebellar circuitry in itself is here summarized as a gigantic associative memory element, primarily consisting of the parallel fiber synapses, whereas most other circuitry components, including the climbing fiber system, primarily has the role of maintaining activity balance in the intracerebellar and extracere Bellar circuitry.

Implications on cerebellar function from information coding

One function of the cerebellar cortex is to process information. There are at least two types of information. Temporal information is encoded in the timing pattern of action and synaptic potentials,

Physiology of Cerebellar Reserve: Redundancy and Plasticity of a Modular Machine

Therapeutic strategies potentiating neural substrates potentiating redundant information and synaptic plasticity are outlined, taking advantage of the unique physiological properties of the cerebellum which appears as a modular and potentially reconfiguring brain structure.

Optimal routing to cerebellum-like structures

A general theory of cerebellum-like structures in conjunction with their afferent pathways is developed that predicts the role of the pontine relay to cerebellar cortex and the glomerular organization of the insect antennal lobe and shows that structured compression followed by random expansion is an efficient architecture for flexible computation.

Control of mental activities by internal models in the cerebellum

  • Masao Ito
  • Psychology, Biology
    Nature Reviews Neuroscience
  • 2008
The conceptual bases and experimental evidence for this hypothesis suggest a possible mechanism by which intuition and implicit thought might function and explains some of the symptoms that are exhibited by psychiatric patients.



The cerebellum and the adaptive coordination of movement.

The adaptive role of the cerebellar cortex would appear to be specialized for combining simpler elements of movement into more complex synergies, and also in enabling simple, stereotyped reflex apparatus to respond differently, specifically, and appropriately under different task conditions.

Convergence Of Afferent Paths To Olivo-Cerebellar Complexes

This presentation will be limited to the climbing fibre input to the cerebellum, which has a precise sagittal organization.

Gating of climbing fibre input to cerebellar cortical zones.

  • Richard Apps
  • Biology, Psychology
    Progress in brain research
  • 2000

Models of the cerebellum and motor learning

This article reviews models of the cerebellum and motor learning starting with the landmark papers by Marr and Albus and going through present times, examining current models of synaptic plasticity, credit assignment and the generation of training information and how they could function cooperatively to guide the processes of motor learning.

A computational model of four regions of the cerebellum based on feedback-error learning

We propose a computationally coherent model of cerebellar motor learning based on the feedback-error-learning scheme. We assume that climbing fiber responses represent motor-command errors generated

Recurrent cerebellar architecture solves the motor-error problem

Current views of cerebellar function have been heavily influenced by the models of Marr and Albus, who suggested that the climbing fibre input to the cerebellum acts as a teaching signal for motor

Movement-related gating of climbing fibre input to cerebellar cortical zones

A Role for the Cerebellum in Learning Movement Coordination

  • W. T. Thach
  • Biology, Psychology
    Neurobiology of Learning and Memory
  • 1998
The theory is extended to show how parallel fibers could implement both the coordination of complex movements and the learning of new movements, and would permit optimized complex movement behaviors to respond to specific behavioral contexts rapidly, stereotypically, and automatically.