Anatomical and functional evidence for trace amines as unique modulators of locomotor function in the mammalian spinal cord

@inproceedings{Gozal2014AnatomicalAF,
  title={Anatomical and functional evidence for trace amines as unique modulators of locomotor function in the mammalian spinal cord},
  author={Elizabeth A. Gozal and Brannan E. O'Neill and Michael A. Sawchuk and Hong Zhu and Mallika Halder and Ching-Chieh Chou and Shawn Hochman},
  booktitle={Front. Neural Circuits},
  year={2014}
}
The trace amines (TAs), tryptamine, tyramine, and β-phenylethylamine, are synthesized from precursor amino acids via aromatic-L-amino acid decarboxylase (AADC). We explored their role in the neuromodulation of neonatal rat spinal cord motor circuits. We first showed that the spinal cord contains the substrates for TA biosynthesis (AADC) and for receptor-mediated actions via trace amine-associated receptors (TAARs) 1 and 4. We next examined the actions of the TAs on motor activity using the in… CONTINUE READING