Anatomical, physiological and biochemical studies of the cerebellum from Reeler mutant mouse.

@article{Mariani1977AnatomicalPA,
  title={Anatomical, physiological and biochemical studies of the cerebellum from Reeler mutant mouse.},
  author={Jean Mariani and Françis Cr{\'e}pel and Katsuhiko Mikoshiba and Jean Pierre Changeux and Constantino Sotelo},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={1977},
  volume={281 978},
  pages={
          1-28
        }
}
The cerebellum of the homozygous reeler mouse shows a marked reduction in size and in the number of fissures, its dry mass and DNA content are respectively $\frac{1}{3}$ - $\frac{1}{4}$ and $\frac{1}{7}$ - $\frac{1}{8}$ of those of normal animals. Its high content in the P $_{400}$ protein, which is abundant in the Purkinje cell, indicates that the decrease in cell number associated with the fall in DNA affects primarily the granular cells. The anatomy of the reeler cerebellum is rather unique… CONTINUE READING

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