Anatomic location defines antigen presentation by dendritic cells to T cells in response to intravenous soluble antigens.

@article{Chung2007AnatomicLD,
  title={Anatomic location defines antigen presentation by dendritic cells to T cells in response to intravenous soluble antigens.},
  author={Yeonseok Chung and Jae-Hoon Chang and Byung-Seok Kim and Jung-Mi Lee and Hang-Rae Kim and Chang-Yuil Kang},
  journal={European journal of immunology},
  year={2007},
  volume={37 6},
  pages={1453-62}
}
In the spleen, exogenous antigen is preferentially presented by CD8alpha+CD11b- DC to CD8 T cells and by CD8alpha-CD11b+ DC to CD4 T cells. However, it is not yet clear whether the same rule applies to other secondary lymphoid organs. To address this issue, we first classified secondary lymphoid tissues into three categories based on the expression pattern of CD8alpha and CD11b in C57BL/6 and BALB/c mice: (a) spleen, (b) mesenteric lymph node (MLN) and (c) other peripheral lymph nodes (PLN). We… CONTINUE READING
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