Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

@article{Fei1997AnatomicLO,
  title={Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.},
  author={Hong Fei and Hirotaka James Okano and Cheng Li and Geun Hyeog Lee and Chengquan Zhao and Robert Darnell and Jeffrey M. Friedman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 13},
  pages={7001-5}
}
Leptin's effects are mediated by interactions with a receptor that is alternatively spliced, resulting in at least five different murine forms: Ob-Ra, Ob-Rb, Ob-Rc, Ob-Rd, and Ob-Re. A mutation in one splice form, Ob-Rb, results in obesity in mice. Northern blots, RNase protection assays, and PCR indicate that Ob-Rb is expressed at a relatively high level in hypothalamus and low level in several other tissues. Ob-Ra is expressed ubiquitously, whereas Ob-Rc, -Rd, and -Re RNAs are only detectable… CONTINUE READING
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