Anatomic heterogeneity of vascular aging: role of nitric oxide and endothelin.

@article{Barton1997AnatomicHO,
  title={Anatomic heterogeneity of vascular aging: role of nitric oxide and endothelin.},
  author={Matthias Barton and Francesco Cosentino and Ralf Peter Brandes and Pierre Moreau and Sidney Shaw and Thomas Felix L{\"u}scher},
  journal={Hypertension},
  year={1997},
  volume={30 4},
  pages={817-24}
}
We investigated the effects of aging, a cardiovascular risk factor, on vascular function with regard to endothelial nitric oxide synthase (eNOS), superoxide dismutase (SOD), and endothelin (ET-1) in aorta and femoral artery of the rat. Concentration-response curves to acetylcholine, calcium ionophore A23187, norepinephrine, ET-1, big endothelin, sodium nitroprusside, and exogenous SOD were obtained. Expression of eNOS mRNA was analyzed by reverse-transcription polymerase chain reaction, SOD… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 100 extracted citations

Similar Papers

Loading similar papers…