Anatomic compression caused by high-volume convection-enhanced delivery to the brain.

@article{Valles2009AnatomicCC,
  title={Anatomic compression caused by high-volume convection-enhanced delivery to the brain.},
  author={Francisco E Valles and Massimo S Fiandaca and John R. Bringas and Peter Dickinson and Richard A Lecouteur and Robert J. Higgins and Mitchel S. Berger and John R. Forsayeth and Krystof S. Bankiewicz},
  journal={Neurosurgery},
  year={2009},
  volume={65 3},
  pages={579-85; discussion 585-6}
}
OBJECTIVE Our group has pioneered the use of gadoteridol-loaded liposomes (GDLs) in convection-enhanced delivery (CED) using real-time magnetic resonance imaging (MRI) to visualize the distribution of therapeutic agents in nonhuman primate and canine brains. We have shown that this procedure is highly predictable and safe. In the course of recent studies, however, we noted that infusion of large volumes caused local anatomic alterations, such as ventricular compression, to occur. This article… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Similar Papers

Loading similar papers…